CBDH, A New Cannabinoid For Pain, Has Been Found in Cannabis

Article by Travis Cesarone, Cannabis Life Network

CBDH, A NEW CANNABINOID FOR PAIN, HAS BEEN FOUND IN CANNABIS TRAVIS CESARONEFEBRUARY 7, 2021 CANNABIS 101CANNABIS NEWSCBD NEWSEDUCATIONFEATUREDHEALTHHEALTH & SEXMARIJUANA NEWSSCIENCE0 VIEWS We reported on the much-discussed scientific discovery of a THC analog thirty times more efficacious than the infamous D9-THC. An earlier study found THCP, as well as CBDP, which are larger forms of THC and CBD, respectively. Now, the same team of researchers from Italy bridged a gap between regular CBD and CBDP. They found a unique form of THC as well as CBDH, a new cannabinoid for pain.

We reported on the much-discussed scientific discovery of a THC analog thirty times more efficacious than the infamous D9-THC. An earlier study found THCP, as well as CBDP, which are larger forms of THC and CBD, respectively. Now, the same team of researchers from Italy bridged a gap between regular CBD and CBDP. They found a unique form of THC as well as CBDH, a new cannabinoid for pain.

The size of the cannabinoid depends, mostly, on the number of carbon atoms. Regular THC and CBD have side chains that consist of five carbon atoms, and the ‘phorol‘ cannabinoids contain seven. Whereas, CBDH (cannabidihexol) is a hexyl cannabinoid with a six-carbon sidechain. (1)

New THC found without luck

Adding to the discovery, the team also found THCH (Δ9– tetrahydrocannabihexol). However, the quantity they collected was insufficient for further tests. It is still unknown if THCH is an intoxicant; potent like THC or even THCP. In any case, the new variants came as no surprise considering a cannabinoid that resembles THCH was synthesized in 1949. This artificial substance, known as parahexyl, is psychoactive and similar in structure to THCH. So, the researchers decided to check. They had to make sure they were looking at new natural analogs of THC and CBD, not some previously known methylated groups.

The Regional European Development Fund financed the research project in Florence, Italy. The team studied a strain known as CIN-RO, which was bred by the Council for Agricultural Research and Economics (CREA) in Rovigo, Italy. And like all cannabis approved for research in the boot-shaped nation, the Italian Military cultivated and provided the cannabis.

CBDH or bust

When the team isolated CBDH, on the other hand, they collected enough to study its effects on mice. Interest that the researchers took in CBDH in this study contrasted the team’s research on phorol cannabinoids (THCP) one year prior. The earlier scientific discovery disregarded CBDP for its lack of cannabinoid receptor activity. But, regular CBD, with a five-carbon chain, lacks true activity at the cannabinoid receptor and instead has an allosteric relationship that took decades for man to truly appreciate. Now, the market is flooded and stocks have gone to mushrooms.

Read the full article here.

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