Article by Cannabis Culture
What makes detoxing from marijuana so hard?
There are 3 major issues with most detox products attempting to remove cannabis from your system:
1. High lipophilicity of metabolites – Simply put, THC is fat soluble and the metabolites tend to get stuck in fat cells as a result.
2. High protein binding of metabolites in the blood stream to albumin – your body can only eliminate free unattached THC through the kidney and bowel.
3. “Bottleneck” of metabolite formation in the liver. In order for your body to clear THC your liver has to turn it into a variety of more water soluble metabolites.
Depending on the level of usage and the person in question (age, gender, size etc.) the half-life or time the drug stays in your body varies greatly. A one-time user typically taking 3-5 days to test negative, infrequent use possibly taking more like a week to 10 days, and daily consumption can take several weeks to well over a month. There are also case reports of well over a month to 2 months in large (over 200 pound) and heavy users (daily or multiple times daily).
What can you do?
Dilution – has its limits. If you over dilute your urine the site won’t accept the sample, as it won’t meet urine creatinine and specific gravity requirements for validity. Fiber – this helps to clear more drug through the bowel and helps bind some.